You're taking the problem upside down !

Use triggers for things that need to be triggered automatically all the time.

Otherwise use shortcuts to execute things at will.

By definition, there's no shortcut to enable or disable triggers

Well then figure out the logic and create a script ;-)

a trigger can call a script, a script can make a decision based on say a status or variable to do what your initial trigger does , have a shortcut ( hotkey) to change that state/variable and let the script again act based on that state ;-)

That's the beauty of vMix , you want something special it lets you do that one way or another

We didn't

Can this be done automatically?
Manually inconvenient, you can forget.

It should have been clear by now that there is no way to activate/de-active a trigger by means of a shortcut or function
A script can perform all the actions of a trigger with the advantage of making a decision based on a criteria !
You mention based on the content of a cell , check out "scripting for dummies" post in this forum where you can find the solution

And how would one envision that , a shortcut to activate/deactivates them all or only specified ones etc , keeping track of them all or just a few ....

Triggers activate all the same functions that can be called with shortcuts or a script so let the trigger call a script and one can go as simple or complex as one wants , build in certain criteria to just ignore some or all function calls. The latest addition of dynamic inputs and values has even greatly expanded the options of creating complex logic based on a status or situation automatically.

You could also create shortcut transition chains that would take a source "clean" for use during replays, then come out to a source "dirty". This would remove the need for your triggers on your source.

I'm very frustrated by people who think they know how people should do their workflows. The feature to temporarily enable and disable triggers is without a doubt useful. Why? Well I use audio triggers from a dozen mics to automatically switch between two PTZ cameras as well as automatically switch between PTZ presets. There are times during a live production where I want to control the cameras manually and since I still need the mic inputs the only option would be disabling triggers while I want manual control. Switching between different presets would interrupt the live stream. Even if a script can be used to replace the audio triggers, this seem like overkill to to do something rather simple that plenty of people are requesting.