I've run vMix on ESXi and it works but with some caveats.

PCIe passthru can be an absolute pain, especially for hardware that's not typically used in virtualized environments (like a Decklink card- which is doable).

You need to make sure that the hypervisor's CPU scheduler puts _nothing_ else on the physical cores you're dedicating to your vMix VM.

Any weird issues you have with "the capture card had an issue and I need to restart vMix" are now "I need to reboot the entire host because the PCIe card doesn't have the ability to reset without an entire bus reset".

It's also worth noting that vMix has official documentation on running vMix in a VM so if you're not dealing with capture hardware you should have a good experience (whether local or cloud): https://www.vmix.com/kno...azon-ec2--quick-overview